Results
| PMID | 25218120 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 17 |
| Population details | 17 (10 women with endometriosis, 7 women without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | TNF, VEGFA |
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Biomed Pharmacother. 2014 Sep;68(7):899-904. doi: 10.1016/j.biopha.2014.08.005. da Silva, Claudia Maria| Vilaca Belo, Andrezza| Passos Andrade, Silvia| Peixoto Campos, Paula| Cristina Franca Ferreira, Marcia| Lopes da Silva-Filho, Agnaldo| Mendonca Carneiro, Marcia Department of Obstetrics and Gynecology, School of Medicine, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190, Santa Efigenia, Belo Horizonte, Minas Gerais, Brazil.| Department of Obstetrics and Gynecology, School of Medicine, The aim of this study was to evaluate the presence of myeloperoxidase (MPO), N-acetyl-beta-D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with (n=10) and without (n=7) endometriosis. NAG and MPO activities were evaluated by enzymatic methods, whereas TNF-alpha and VEGF by immunoassay. No significant differences were found for these markers, neither in menstrual nor in peripheral blood between groups. Menstrual blood NAG (P=0.039) and MPO (P=0.0117) activities in the endometriosis group were significantly higher than in peripheral blood. NAG and MPO presented positive linear correlation in peripheral (P=0.07; r=0.641) and menstrual blood (P=0.01; r=0.603). These findings point to the existence of an increased local inflammatory activity in women with endometriosis. Mesh Terms: Adult| Biomarkers/*metabolism| Endometriosis/*metabolism| Female| Humans| Inflammation/*metabolism| Menstrual Cycle/*metabolism| Middle Aged| Neoplasm Proteins/metabolism| Neovascularization, Pathologic/*metabolism| Peroxidase/metabolism| Tumor |
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